PDT is being looked at as a new treatment for prostate cancer. It has been used by a small number of groups in different parts of the world. Some groups have used PDT as a first treatment for prostate cancer. Others have used as a treatment after radiotherapy has failed. Different groups have used different photosensitisers.
Vascular targeteted PDT with Tookad has been tried in patients whose prostate cancer came back after radiotherapy. It caused a reduction in PSA and MRI scans showed evidence of killing prostate cancer cells (cancer and normal cells). It is not yet known whether PDT could be as effective as other treatments for prostate cancer. It is hoped that it will be as effective as traditional treatments, but have fewer side effects, such as incontinence and problems with erections. Studies are being carried out with patients with prostate cancer at present.
Are there any side effects?
Photodynamic therapy can have a number of side effects. These can be considered in two groups:
1) Those that are related to the photosensitising drug:
Side effects seen with WST-09 include a change in liver function which is temporary; a drop in blood pressure in some patients; sensitivity to sunlight and room light, for a few hours at the most.
2) Those that are related to the procedure :
This includes effects on the urine stream, blood in the urine and frequency of passing urine, which are usually temporary. Effects on sexual function are also possible.
